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human CSNK1E shRNA silencing Adenovirus

Name 
Ad-h-CSNK1E-shRNA
Cat No 
shADV-214270
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human CSNK1E.

shADV-214270
Ad-h-CSNK1E-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human CSNK1E (casein kinase 1 epsilon). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
casein kinase I isoform epsilon; CKIe; CKIepsilon; CKI-epsilon; HCKIE
Description (eCommerce)
CKI epsilon is a member of the casein kinase 1 (CK1) serine/threonine kinase family of proteins. In mammals, there are seven distinct genes that represent the CK1 family: alpha, beta, gamma-1, gamma-2, gamma-3, delta, and epsilon. CKI epsilon phosphorylates a large number of proteins and is involved in pathways involving Wnt and AKT. CKI epsilon has been found to bind and phosphorylate the circadian protein, Period, and the Wnt signaling protein, Dsh. In the Wnt pathway, CKI epsilon activity is required for the full activation of Dsh and downstream signaling effects.
Description (Vector)
CSNK1E is a serine/threonine protein kinase and a member of the casein kinase I protein family, whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is found in the cytoplasm as a monomer and can phosphorylate a variety of proteins, including itself. This protein has been shown to phosphorylate period, a circadian rhythm protein. Two transcript variants encoding the same protein have been found for this gene.
Gene ID
1454
Gene Name (eCommerce)
casein kinase 1 epsilon
Gene Name (Vector)
casein kinase 1 epsilon
Gene Symbol
CSNK1E
HGNC ID
HGNC:2453
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1251
ORF Size (bp)
1251 bp
Protein Name (eCommerce)
Casein kinase I isoform epsilon
RefSeq ID
NM_152221
RefSeq Synonyms
NM_152221, NM_001894, BC006490,
Research Areas
Cell Cycle,DNA Damage/Repair,EPO Signaling,FoxO Signaling,Hedgehog Signaling,Hippo Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,p53 Signaling,Signal Transduction,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
CKI epsilon is a member of the casein kinase 1 (CK1) serine/threonine kinase family of proteins. In mammals, there are seven distinct genes that represent the CK1 family: alpha, beta, gamma-1, gamma-2, gamma-3, delta, and epsilon. CKI epsilon phosphorylates a large number of proteins and is involved in pathways involving Wnt and AKT. CKI epsilon has been found to bind and phosphorylate the circadian protein, Period, and the Wnt signaling protein, Dsh. In the Wnt pathway, CKI epsilon activity is required for the full activation of Dsh and downstream signaling effects.
UniGene ID
Hs.474833
UniProt ID (eCommerce)
P49674

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.