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human NFYC shRNA silencing Adenovirus

Name 
Ad-h-NFYC-shRNA
Cat No 
shADV-214113
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human NFYC.

shADV-214113
Ad-h-NFYC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human NFYC (nuclear transcription factor Y subunit gamma). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CAAT box DNA-binding protein subunit C; CBFC; CBF-C; CCAAT binding factor subunit C; CCAAT transcription binding factor subunit gamma; H1TF2A; HAP5; histone H1 transcription factor large subunit 2A; HSM; NF-YC; nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma; nuclear transcription factor Y, gamma; transactivator HSM-1; transactivator HSM-1/2; transcription factor NF-Y, C subunit
Description (eCommerce)
Nuclear transcription factor Y gamma (NF-YC) is a subunit of the NF-Y heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. The NF-Y factor binds the CCAAT box with high specificity and affinity, and it is the major CCAAT-binding activator. All 3 subunits are essential for CCAAT binding. NF-Y plays a role in regulating several cell-cycle regulated genes such as CDC2, CDC25A/B/C, cyclin A2, cyclin B1/B2, and E2F1.
Description (Vector)
NFYC encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4802
Gene Name (eCommerce)
nuclear transcription factor Y subunit gamma
Gene Name (Vector)
nuclear transcription factor Y subunit gamma
Gene Symbol
NFYC
HGNC ID
HGNC:7806
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
Protein Name (eCommerce)
Nuclear transcription factor Y subunit gamma
RefSeq ID
NM_014223
RefSeq Synonyms
NM_014223, NM_001308115, NM_001308114, NM_001142590, NM_001142589, NM_001142588, NM_001142587, BC005003,
Research Areas
Antigen Processing and Presentation,Immunology,Metabolism/Metabolic Process,Protein Folding,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,immunology,metabolism,signal_transduction,transcription_translation
Species
human
Target Sentence
Nuclear transcription factor Y gamma (NF-YC) is a subunit of the NF-Y heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. The NF-Y factor binds the CCAAT box with high specificity and affinity, and it is the major CCAAT-binding activator. All 3 subunits are essential for CCAAT binding. NF-Y plays a role in regulating several cell-cycle regulated genes such as CDC2, CDC25A/B/C, cyclin A2, cyclin B1/B2, and E2F1.
UniGene ID
Hs.233458
UniProt ID (eCommerce)
Q13952

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.