human LEP shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LEP.
shADV-213830
Ad-h-LEP-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LEP (leptin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
LEPD; OB; OBS
Description (Vector)
LEP encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. LEP has also been linked to type 2 diabetes mellitus development.
Gene ID
3952
Gene Name (Vector)
leptin
Gene Symbol
LEP
HGNC ID
HGNC:6553
ORF Size (aa)
504
RefSeq ID
NM_000230
RefSeq Synonyms
NM_000230, BC069527, BC069452, BC069323, BC060830,
Species
human
UniGene ID
Hs.194236
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.