human LAT shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human LAT.
shADV-213702
Ad-h-LAT-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human LAT (linker for activation of T-cells). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
36 kDa phospho-tyrosine adapter protein; 36 kDa phospho-tyrosine adaptor protein; IMD52; LAT1; linker for activation of T cells, transmembrane adaptor; linker for activation of T-cells family member 1; p36-38; pp36
Description (eCommerce)
LAT is required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43561].
Description (Vector)
LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms.
Gene ID
27040
Gene Name (eCommerce)
linker for activation of T cells
Gene Name (Vector)
linker for activation of T-cells
Gene Symbol
LAT
HGNC ID
HGNC:18874
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
702
Protein Name (eCommerce)
Linker for activation of T-cells family member 1
RefSeq ID
NM_014387
RefSeq Synonyms
NM_014387, NM_001014989, NM_001014988, NM_001014987, BC011563,
Research Areas
Apoptosis,Fc Receptor Signaling,Immunology,Innate Immunity,Neurobiology,NF-kB Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
LAT is required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43561].
UniGene ID
Hs.632179
UniProt ID (eCommerce)
O43561
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.