human KIR2DL4 shRNA silencing Adenovirus

Name 
Ad-h-KIR2DL4-shRNA
Cat No 
shADV-213129
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIR2DL4.

shADV-213129
Ad-h-KIR2DL4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIR2DL4 (killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CD158D; G9P; KIR-103AS; KIR-2DL4; KIR103; KIR103AS
Description (Vector)
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.
Gene ID
3805
Gene Name (Vector)
killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4
Gene Symbol
KIR2DL4
HGNC ID
HGNC:6332
ORF Size (aa)
1134
ORF Size (bp)
1134 bp
RefSeq ID
NM_002255
RefSeq Synonyms
NM_002255, NM_001080772, NM_001080770, BC041611,
Species
human
UniGene ID
Hs.661219

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.