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human KIF2A shRNA silencing Adenovirus

Name 
Ad-h-KIF2A-shRNA
Cat No 
shADV-213092
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIF2A.

shADV-213092
Ad-h-KIF2A-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIF2A (kinesin family member 2A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CDCBM3; HK2; KIF2; kinesin heavy chain member 2A; Kinesin, heavy chain, 2; kinesin-2; kinesin-like protein KIF2A
Description (eCommerce)
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF2A has been demonstrated to be essential for spindle assembly and chromosome movement.
Description (Vector)
KIF2A is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene.
Gene ID
3796
Gene Name (eCommerce)
kinesin family member 2A
Gene Name (Vector)
kinesin family member 2A
Gene Symbol
KIF2A
HGNC ID
HGNC:6318
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2040
ORF Size (bp)
2040 bp
Protein Name (eCommerce)
Kinesin-like protein KIF2A
RefSeq ID
NM_004520
RefSeq Synonyms
NM_004520, NM_001243953, NM_001243952, NM_001098511, BC031828,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cell Division,Cytoskeleton,Immunology,Neurobiology,Neurodevelopment,Neurogenesis,PLK1 Signaling,Signal Transduction,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF2A has been demonstrated to be essential for spindle assembly and chromosome movement.
UniGene ID
Hs.558351
UniProt ID (eCommerce)
O00139

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.