human KIF1B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KIF1B.
shADV-213081
Ad-h-KIF1B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KIF1B (kinesin family member 1B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMT2; CMT2A; CMT2A1; HMSNII; kinesin superfamily protein KIF1B; kinesin-like protein KIF1B; KLP; NBLST1
Description (eCommerce)
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF1B has been identified as the cause of Charcot-Marie-Tooth disease type 2A, a human hereditary neuropathy.
Description (Vector)
KIF1B encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1.
Gene ID
23095
Gene Name (eCommerce)
kinesin family member 1B
Gene Name (Vector)
kinesin family member 1B
Gene Symbol
KIF1B
HGNC ID
HGNC:16636
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3462
ORF Size (bp)
3462 bp
Protein Name (eCommerce)
Kinesin-like protein KIF1B
RefSeq ID
NM_015074
RefSeq Synonyms
NM_183416, NM_015074, BC115395, BC001415,
Research Areas
Apoptosis,Cytoskeleton,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,Transport
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
human
Target Sentence
The kinesin superfamily of proteins consists of over forty KIF motor proteins that function in intracellular transport along microtubules. Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. KIF1B has been identified as the cause of Charcot-Marie-Tooth disease type 2A, a human hereditary neuropathy.
UniGene ID
Hs.97858
UniProt ID (eCommerce)
O60333
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.