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human KIAA1524 shRNA silencing Adenovirus

Name 
Ad-h-KIAA1524-shRNA
Cat No 
shADV-213016
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KIAA1524.

shADV-213016
Ad-h-KIAA1524-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KIAA1524 (KIAA1524). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cancerous inhibitor of PP2A; cancerous inhibitor of protein phosphatase 2A; KIAA1524; p90; p90 autoantigen; protein CIP2A
Description (eCommerce)
CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.
Gene ID
57650
Gene Name (eCommerce)
cell proliferation regulating inhibitor of protein phosphatase 2A
Gene Name (Vector)
KIAA1524
Gene Symbol
KIAA1524
HGNC ID
HGNC:29302
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2718
ORF Size (bp)
2718 bp
Protein Name (eCommerce)
Protein CIP2A
RefSeq ID
NM_020890
RefSeq Synonyms
NM_020890, BC136371, BC130564,
Research Areas
Cancer,Cell Biology,Transport,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,cell_biology
Species
human
Target Sentence
CIP2A (cancerous inhibitor of PP2A) was originally identified as p90, a cytoplasmic autoantigen found in the serum from a cancer patient. It was later described as a protein that interacted with the c-myc oncogene and functioned as an inhibitor of protein phosphatase 2A (PP2A) activity. Inhibition of PP2A phosphatase activity by CIP2A prevents c-myc phosphorylation and counteracts c-myc proteolytic degradation, thereby stabilizing c-myc and promoting cell growth and transformation. CIP2A is found to be overexpressed in some human malignancies and is thus classified as an oncogene that may be an important contributor to tumor formation.
UniGene ID
Hs.591308
UniProt ID (eCommerce)
Q8TCG1

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.