human LEO1 Over-expression AAV

Name 
AAV-h-LEO1
Cat No 
AAV-213829
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human LEO1.

AAV-213829
AAV-h-LEO1

Ready-to-use AAV expressing Human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Leo1 Paf1/RNA polymerase II complex component; Leo1, Paf1/RNA polymerase II complex component, homolog; RDL; replicative senescence down-regulated leo1-like protein; RNA polymerase-associated protein LEO1
Description (eCommerce)
Leo1 is a component of the Paf/RNA polymerase II complex which consists of at least Leo1, CDC73, PAF1, and CTR9. The PAF1/RNA polymerase II complex plays a role in transcriptional initiation and elongation, histone methylation, and RNA processing.
Description (Vector)
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 (PubMed 15632063)).(supplied by OMIM, Mar 2008)
Gene ID
123169
Gene Name (eCommerce)
LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Name (Vector)
LEO1 homolog, Paf1/RNA polymerase II complex component
Gene Symbol
LEO1
HGNC ID
HGNC:30401
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2001
ORF Size (bp)
2001 bp
Protein Name (eCommerce)
RNA polymerase-associated protein LEO1
RefSeq ID
NM_138792
RefSeq Synonyms
NM_138792, NM_001323904, NM_001323903, NM_001286430, BC018147,
Research Areas
Histone Modification,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Wnt Signaling
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Leo1 is a component of the Paf/RNA polymerase II complex which consists of at least Leo1, CDC73, PAF1, and CTR9. The PAF1/RNA polymerase II complex plays a role in transcriptional initiation and elongation, histone methylation, and RNA processing.
UniGene ID
Hs.567662
UniProt ID (eCommerce)
Q8WVC0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.