human KIAA1033 shRNA silencing Adenovirus

Name 
Ad-h-KIAA1033-shRNA
Cat No 
shADV-212971
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human WASHC4.

shADV-212971
Ad-h-KIAA1033-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human WASHC4 (WASH complex subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
76
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
KIAA1033; MRT43; strumpellin and WASH-interacting protein; SWIP; WASH complex subunit 4; WASH complex subunit 7; WASH complex subunit SWIP
Description (eCommerce)
KIAA1033/WASH complex subunit 7 acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes sems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093)  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q2M389].
Gene ID
23325
Gene Name (eCommerce)
WASH complex subunit 4
Gene Name (Vector)
WASH complex subunit 4
Gene Symbol
WASHC4
HGNC ID
HGNC:29174
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3525
ORF Size (bp)
3525 bp
Protein Name (eCommerce)
WASH complex subunit 7
RefSeq ID
NM_015275
RefSeq Synonyms
NM_015275, NM_001293640, BC143373, BC104994, BC104992,
Research Areas
Cell Biology
Research Areas (Faceted)
cell_biology
Species
human
Target Sentence
KIAA1033/WASH complex subunit 7 acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes sems to inhibit WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization, and which is involved in the regulation of the fission of tubules that serve as transport intermediates during endosome sorting (PubMed:19922875, PubMed:20498093)  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q2M389].
UniGene ID
Hs.12144
UniProt ID (eCommerce)
Q2M389

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.