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human KDM4C shRNA silencing Adenovirus

Name 
Ad-h-KDM4C-shRNA
Cat No 
shADV-212844
Availability
Immediate
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human KDM4C.

shADV-212844
Ad-h-KDM4C-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KDM4C (lysine demethylase 4C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GASC1; GASC-1 protein; gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; jumonji domain-containing protein 2C; lysine (K)-specific demethylase 4C; lysine-specific demethylase 4C; TDRD14C; tudor domain containing 14C
Description (eCommerce)
JMJD2C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2C, also known as GASC1 (gene amplified in squamous cell carcinoma), has been found to be amplified in several esophageal squamous carcinomas and inhibition of JMJD2C/GASC1 expression results in decreased cellular proliferation.
Description (Vector)
KDM4C is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants.
Gene ID
23081
Gene Name (eCommerce)
lysine demethylase 4C
Gene Name (Vector)
lysine demethylase 4C
Gene Symbol
KDM4C
HGNC ID
HGNC:17071
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3171
ORF Size (bp)
3171 bp
Protein Name (eCommerce)
Lysine-specific demethylase 4C
RefSeq ID
NM_015061
RefSeq Synonyms
NM_015061, NM_001304341, NM_001304340, NM_001304339, NM_001146696, NM_001146695, NM_001146694, BC143571, BC104861, BC104859,
Research Areas
Cancer,Chromatin Remodeling,Histone Modification,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,genetics,transcription_translation
Species
human
Target Sentence
JMJD2C is a member of the jumonji (jmj) domain containing gene family of histone demethylases that plays a role in chromatin regulation and influences transcriptional activation and suppression. Some recently characterized members of the jmj family include JARID1A/RBP2, JARID1C, JMJD1A, JMJD1B, JMJD1C, JMJD2A, JMJD2C and JMJD2D. JMJD2C, also known as GASC1 (gene amplified in squamous cell carcinoma), has been found to be amplified in several esophageal squamous carcinomas and inhibition of JMJD2C/GASC1 expression results in decreased cellular proliferation.
UniGene ID
Hs.709425
UniProt ID (eCommerce)
Q9H3R0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.