human KCNQ1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KCNQ1.
shADV-212771
Ad-h-KCNQ1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KCNQ1 (potassium voltage-gated channel subfamily Q member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATFB1; ATFB3; JLNS1; KCNA8; KCNA9; Kv1.9; Kv7.1; KVLQT1; LQT; LQT1; RWS; SQT2; WRS
Description (Vector)
KCNQ1 encodes a voltage-gated potassium channel required for repolarization phase of the cardiac action potential. This protein can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. Mutations in this gene are associated with hereditary long QT syndrome 1 (also known as Romano-Ward syndrome), Jervell and Lange-Nielsen syndrome, and familial atrial fibrillation. KCNQ1 exhibits tissue-specific imprinting, with preferential expression from the maternal allele in some tissues, and biallelic expression in others. KCNQ1 is located in a region of chromosome 11 amongst other imprinted genes that are associated with Beckwith-Wiedemann syndrome (BWS), and itself has been shown to be disrupted by chromosomal rearrangements in patients with BWS. Alternatively spliced transcript variants have been found for this gene.
Gene ID
3784
Gene Name (Vector)
potassium voltage-gated channel subfamily Q member 1
Gene Symbol
KCNQ1
HGNC ID
HGNC:6294
ORF Size (aa)
1650
ORF Size (bp)
1650 bp
RefSeq ID
NM_000218
RefSeq Synonyms
NM_181798, NM_000218, BC113545, BC111847,
Species
human
UniGene ID
Hs.95162
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.