human KCNMB4 shRNA silencing Adenovirus

Name
Ad-h-KCNMB4-shRNA

Cat No
shADV-212763

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human KCNMB4.

shADV-212763

Ad-h-KCNMB4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human KCNMB4 (potassium calcium-activated channel subfamily M regulatory beta subunit 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit.

Gene ID

27345

Gene Name (Vector)

potassium calcium-activated channel subfamily M regulatory beta subunit 4

Gene Symbol

KCNMB4

HGNC ID

HGNC:6289

ORF Size (aa)

633

RefSeq ID

NM_014505

RefSeq Synonyms

NM_014505, BC050621, BC042446,

Species

human

UniGene ID

Hs.525529

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.