human KCNMA1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KCNMA1.
shADV-212758
Ad-h-KCNMA1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
bA205K10.1; big potassium channel alpha subunit; BK channel; BK channel alpha subunit; BKCA alpha; BKCA alpha subunit; BKTM; CADEDS; calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel, subfamily M subunit alpha-1; hSlo; k(VCA)alpha; KCa1.1; Maxi K channel; MaxiK; maxi-K channel HSLO; mSLO1; PNKD3; potassium channel, calcium activated large conductance subfamily M alpha, member 1; potassium large conductance calcium-activated channel, subfamily M, alpha member 1; SAKCA; SLO; slo homolog; SLO1; SLO-ALPHA; slowpoke homolog; stretch-activated Kca channel; uncharacterized protein
Description (eCommerce)
KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) is a potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. KCNMA1 is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. KCNMA1 therefore contributes to repolarization of the membrane potential, and plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity.1, maxi K channel, MaxiK, Slo-alpha, slo1, slowpoke homolog, Slo homolog, and hSlo [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12791].
Description (Vector)
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
3778
Gene Name (eCommerce)
potassium calcium-activated channel subfamily M alpha 1
Gene Name (Vector)
potassium calcium-activated channel subfamily M alpha 1
Gene Symbol
KCNMA1
HGNC ID
HGNC:6284
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3627
ORF Size (bp)
3627 bp
Protein Name (eCommerce)
Calcium-activated potassium channel subunit alpha-1
RefSeq ID
NM_002247
RefSeq Synonyms
NM_002247, NM_001322839, NM_001322838, NM_001322837, NM_001322836, NM_001322835, NM_001322832, NM_001322830, NM_001322829, NM_001271522, NM_001271521, NM_001271520, NM_001271519, NM_001271518, NM_001161353, NM_001161352, NM_001014797, BC144496, BC137137, BC137115, BC062659,
Research Areas
Apoptosis,Cardiovascular,Epilepsy,Hypoxia,Neurobiology,Transport
Research Areas (Faceted)
cardiovascular,cell_biology,neurobiology
Species
human
Target Sentence
KCNMA1 (potassium large conductance calcium-activated channel, subfamily M, alpha member 1) is a potassium channel activated by both membrane depolarization or increase in cytosolic Ca2+ that mediates export of K+. KCNMA1 is also activated by the concentration of cytosolic Mg2+. Its activation dampens the excitatory events that elevate the cytosolic Ca2+ concentration and/or depolarize the cell membrane. KCNMA1 therefore contributes to repolarization of the membrane potential, and plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity.1, maxi K channel, MaxiK, Slo-alpha, slo1, slowpoke homolog, Slo homolog, and hSlo [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q12791].
UniGene ID
Hs.144795
UniProt ID (eCommerce)
Q12791
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.