human KARS shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human KARS.
shADV-212623
Ad-h-KARS-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human KARS (lysyl-tRNA synthetase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMTRIB; DFNB89; KARS1; KARS2; KRS; lysine tRNA ligase; lysine--tRNA ligase; lysRS; Lysyl-tRNA synthetase
Description (eCommerce)
KARS is an aminoacyl-tRNA synthetase that functions to charge tRNAs with their cognate amino acids.
Description (Vector)
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
3735
Gene Name (eCommerce)
lysyl-tRNA synthetase
Gene Name (Vector)
lysyl-tRNA synthetase
Gene Symbol
KARS
HGNC ID
HGNC:6215
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1794
ORF Size (bp)
1794 bp
Protein Name (eCommerce)
Lysine--tRNA ligase
RefSeq ID
NM_005548
RefSeq Synonyms
NM_005548, NM_001130089, BC004132,
Research Areas
Cytoskeleton,Gene Expression,Host-Virus Interactions,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment,RNA Processing,Translational Control,tRNA Binding
Research Areas (Faceted)
cell_biology,developmental_biology,genetics,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
KARS is an aminoacyl-tRNA synthetase that functions to charge tRNAs with their cognate amino acids.
UniGene ID
Hs.3100
UniProt ID (eCommerce)
Q15046
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.