human IRF3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IRF3.
shADV-212406
Ad-h-IRF3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IRF3 (interferon regulatory factor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IIAE7; interferon regulatory factor 3; IRF-3
Description (eCommerce)
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
Description (Vector)
IRF3 encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
3661
Gene Name (eCommerce)
interferon regulatory factor 3
Gene Name (Vector)
interferon regulatory factor 3
Gene Symbol
IRF3
HGNC ID
HGNC:6118
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1359
ORF Size (bp)
1359 bp
Protein Name (eCommerce)
Interferon regulatory factor 3
RefSeq ID
NM_001571
RefSeq Synonyms
NM_001571, NM_001197128, NM_001197127, NM_001197126, NM_001197125, NM_001197124, NM_001197123, NM_001197122, BC071721, BC009395, BC000660,
Research Areas
Cancer,Cytokine Signaling,DNA Damage/Repair,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,NF-kB Signaling,Response to Virus,Toll-like Receptor Signaling,Transcription Factor/Regulator,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cell_biology,genetics,immunology,infectious_disease,signal_transduction,transcription_translation
Species
human
Target Sentence
Interferon regulatory factor 3 (IRF3) is a member of the IRF family of transcription factors that plays a critical role in immune cell function and development. IRF3 mediates interferon-stimulated response element (ISRE) promoter activation and functions as a molecular switch for antiviral activity.
UniGene ID
Hs.75254
UniProt ID (eCommerce)
Q14653
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.