human IL6ST shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IL6ST.
shADV-212204
Ad-h-IL6ST-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IL6ST (interleukin 6 signal transducer). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD antigen CD130; CD130; CD130 antigen; CDW130; GP130; gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form; gp130, oncostatin M receptor; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6RB; IL-6R-beta; interleukin receptor beta chain; interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; membrane glycoprotein 130; membrane glycoprotein gp130; oncostatin-M receptor subunit alpha
Description (eCommerce)
GP130/CD130/IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. [taken from NCBI Entrez Gene (Gene ID: 3572)].
Description (Vector)
IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17.
Gene ID
3572
Gene Name (eCommerce)
interleukin 6 signal transducer
Gene Name (Vector)
interleukin 6 signal transducer
Gene Symbol
IL6ST
HGNC ID
HGNC:6021
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2757
ORF Size (bp)
2757 bp
Protein Name (eCommerce)
Interleukin-6 receptor subunit beta
RefSeq ID
NM_002184
RefSeq Synonyms
NM_175767, NM_002184, NM_001190981, BC117404, BC117402,
Research Areas
Apoptosis,Autophagy,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cytokine Signaling,Host-Virus Interactions,Immunology,Interleukin Signaling,JAK-STAT Signaling,Leukemia,Metabolism/Metabolic Process,Neurobiology,Notch Signaling,Signal Transduction,Viral Carcinogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
GP130/CD130/IL6ST is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. [taken from NCBI Entrez Gene (Gene ID: 3572)].
UniGene ID
Hs.532082
UniProt ID (eCommerce)
P40189
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.