human IL21R shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IL21R.
shADV-212145
Ad-h-IL21R-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IL21R (interleukin 21 receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD360; NILR
Description (Vector)
IL21R is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2, 4, 7, 9, and 15. This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants have been described.
Gene ID
50615
Gene Name (Vector)
interleukin 21 receptor
Gene Symbol
IL21R
HGNC ID
HGNC:6006
ORF Size (aa)
1617
ORF Size (bp)
1617 bp
RefSeq ID
NM_181079
RefSeq Synonyms
NM_181079, NM_181078, NM_021798, BC004348,
Species
human
UniGene ID
Hs.210546
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.