human IGBP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human IGBP1.
shADV-211904
Ad-h-IGBP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human IGBP1 (immunoglobulin (CD79A) binding protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ALPHA-4; B cell signal transduction molecule alpha 4; bA351K23.1 (immunoglobulin binding protein 1 (CD79A) ); B-cell signal transduction molecule alpha 4; CD79a-binding protein 1; IBP1; immunoglobulin (CD79A) binding protein 1; immunoglobulin-binding protein 1; protein alpha-4; protein phosphatase 2/4/6 regulatory subunit; protein phosphatase 2A, regulatory subunit alpha-4; renal carcinoma antigen NY-REN-16
Description (eCommerce)
Alpha-4 is involved in the rapamycin sensitive mTOR pathway through its association with the PP2Ac phosphatase. Alpha-4 may regulate PP2Ac activity for the cell cycle progression of lymphocytes. Alpha-4 is also associated to surface IgM receptors and is involved in B-cell receptor mediated signal transduction.
Description (Vector)
The proliferation and differentiation of B cells is dependent upon a B-cell antigen receptor (BCR) complex. Binding of antigens to specific B-cell receptors results in a tyrosine phosphorylation reaction through the BCR complex and leads to multiple signal transduction pathways.
Gene ID
3476
Gene Name (eCommerce)
immunoglobulin binding protein 1
Gene Name (Vector)
immunoglobulin (CD79A) binding protein 1
Gene Symbol
IGBP1
HGNC ID
HGNC:5461
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1020
Protein Name (eCommerce)
Immunoglobulin-binding protein 1
RefSeq ID
NM_001551
RefSeq Synonyms
NM_001551, BC004137,
Research Areas
Apoptosis,Cancer,Immunology,Interleukin Signaling,MAPK Signaling,Neurobiology,Signal Transduction
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
Alpha-4 is involved in the rapamycin sensitive mTOR pathway through its association with the PP2Ac phosphatase. Alpha-4 may regulate PP2Ac activity for the cell cycle progression of lymphocytes. Alpha-4 is also associated to surface IgM receptors and is involved in B-cell receptor mediated signal transduction.
UniGene ID
Hs.496267
UniProt ID (eCommerce)
P78318
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.