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human IDS shRNA silencing Adenovirus

Name 
Ad-h-IDS-shRNA
Cat No 
shADV-211780
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IDS.

shADV-211780
Ad-h-IDS-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IDS (iduronate 2-sulfatase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MPS2; SIDS
Description (Vector)
Iduronate-2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Mutations in this X-chromosome gene that result in enzymatic deficiency lead to the sex-linked Mucopolysaccharidosis Type II, also known as Hunter Syndrome. Iduronate-2-sulfatase has a strong sequence similarity with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described.
Gene ID
3423
Gene Name (Vector)
iduronate 2-sulfatase
Gene Symbol
IDS
HGNC ID
HGNC:5389
ORF Size (aa)
939
ORF Size (bp)
939 bp
RefSeq ID
NM_000202
RefSeq Synonyms
NM_006123, NM_001166550, NM_000202, BC006170,
Species
human
UniGene ID
Hs.460960

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.