human IDI1 shRNA silencing Adenovirus

Name 
Ad-h-IDI1-shRNA
Cat No 
shADV-211777
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IDI1.

shADV-211777
Ad-h-IDI1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IDI1 (isopentenyl-diphosphate delta isomerase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
IPP isomerase 1; IPP1; IPPI1; isopentenyl diphosphate dimethylallyl diphosphate isomerase 1; isopentenyl pyrophosphate isomerase 1; isopentenyl-diphosphate Delta-isomerase 1
Description (eCommerce)
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity [taken from NCBI Entrez Gene (Gene ID: 3422)].
Description (Vector)
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity.
Gene ID
3422
Gene Name (eCommerce)
isopentenyl-diphosphate delta isomerase 1
Gene Name (Vector)
isopentenyl-diphosphate delta isomerase 1
Gene Symbol
IDI1
HGNC ID
HGNC:5387
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
687
ORF Size (bp)
687 bp
Protein Name (eCommerce)
Isopentenyl-diphosphate Delta-isomerase 1
RefSeq ID
NM_004508
RefSeq Synonyms
NM_004508, NM_001317957, NM_001317956, NM_001317955, BC057827, BC019227, BC005247,
Research Areas
Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
signal_transduction,metabolism,cell_biology
Species
human
Target Sentence
IDI1 encodes a peroxisomally-localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP), which are the substrates for the successive reaction that results in the synthesis of farnesyl diphosphate and, ultimately, cholesterol. It has been shown in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy that there is reduction in IPP isomerase activity [taken from NCBI Entrez Gene (Gene ID: 3422)].
UniGene ID
Hs.705849
UniProt ID (eCommerce)
Q13907

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.