human HNRNPH1 shRNA silencing Adenovirus

Name 
Ad-h-HNRNPH1-shRNA
Cat No 
shADV-211377
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HNRNPH1.

shADV-211377
Ad-h-HNRNPH1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HNRNPH1 (heterogeneous nuclear ribonucleoprotein H1 (H)). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
epididymis secretory sperm binding protein; heterogeneous nuclear ribonucleoprotein H; heterogeneous nuclear ribonucleoprotein H1 (H); hnRNP H; hnRNPH; HNRPH; HNRPH1
Description (eCommerce)
Heterogeneous nuclear ribonucleoprotein H (hnRNP-H) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-H binds specific cis-sequence elements on pre-mRNA and functions as an accessory factor for splicing by influencing small nuclear ribonucleoprotein (snRNP) binding.
Description (Vector)
HNRNPH1 encodes a member of a subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins that complex with heterogeneous nuclear RNA. These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some may shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNA and is very similar to the family member HNRPF. HNRNPH1 may be associated with hereditary lymphedema type I. Alternatively spliced transcript variants have been described
Gene ID
3187
Gene Name (eCommerce)
heterogeneous nuclear ribonucleoprotein H1
Gene Name (Vector)
heterogeneous nuclear ribonucleoprotein H1 (H)
Gene Symbol
HNRNPH1
HGNC ID
HGNC:5041
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1350
ORF Size (bp)
1350 bp
Protein Name (eCommerce)
Heterogeneous nuclear ribonucleoprotein H
RefSeq ID
NM_005520
RefSeq Synonyms
NM_005520, NM_001257293, BC001348,
Research Areas
Cytoskeleton,Gene Expression,mRNA Processing,mRNA Splicing,RNA Binding,RNA Processing,Spliceosome
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
Heterogeneous nuclear ribonucleoprotein H (hnRNP-H) belongs to a group of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind and complex with heterogeneous nuclear RNA (hnRNA) and play a role in pre-mRNA processing and transport. hnRNP-H binds specific cis-sequence elements on pre-mRNA and functions as an accessory factor for splicing by influencing small nuclear ribonucleoprotein (snRNP) binding.
UniGene ID
Hs.604001
UniProt ID (eCommerce)
P31943

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.