human HLA-DMB shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human HLA-DMB.
shADV-211213
Ad-h-HLA-DMB-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human HLA-DMB (major histocompatibility complex, class II, DM beta). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
D6S221E; RING7
Description (Vector)
HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
Gene ID
3109
Gene Name (Vector)
major histocompatibility complex, class II, DM beta
Gene Symbol
HLA-DMB
HGNC ID
HGNC:4935
ORF Size (aa)
792
ORF Size (bp)
792 bp
RefSeq ID
NM_002118
RefSeq Synonyms
NM_002118, BC027175,
Species
human
UniGene ID
Hs.654428
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.