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human HCST shRNA silencing Adenovirus

Name 
Ad-h-HCST-shRNA
Cat No 
shADV-210880
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human HCST.

shADV-210880
Ad-h-HCST-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human HCST (hematopoietic cell signal transducer). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
DAP10; KAP10; PIK3AP
Description (Vector)
HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
Gene ID
10870
Gene Name (Vector)
hematopoietic cell signal transducer
Gene Symbol
HCST
HGNC ID
HGNC:16977
ORF Size (aa)
282
RefSeq ID
NM_014266
RefSeq Synonyms
NM_014266, NM_001007469, BC065224, BC046348, BC035931,
Species
human
UniGene ID
Hs.117339

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.