human GUCY2D shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GUCY2D.
shADV-210692
Ad-h-GUCY2D-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GUCY2D (guanylate cyclase 2D, retinal). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CORD5; CORD6; CYGD; GUC1A4; GUC2D; LCA; LCA1; RCD2; retGC; RETGC-1; ROS-GC1; ROSGC
Description (Vector)
GUCY2D encodes a retina-specific guanylate cyclase, which is a member of the membrane guanylyl cyclase family. Like other membrane guanylyl cyclases, this enzyme has a hydrophobic amino-terminal signal sequence followed by a large extracellular domain, a single membrane spanning domain, a kinase homology domain, and a guanylyl cyclase catalytic domain. In contrast to other membrane guanylyl cyclases, this enzyme is not activated by natriuretic peptides. Mutations in this gene result in Leber congenital amaurosis and cone-rod dystrophy-6 diseases.
Gene ID
3000
Gene Name (Vector)
guanylate cyclase 2D, retinal
Gene Symbol
GUCY2D
HGNC ID
HGNC:4689
ORF Size (aa)
3309
ORF Size (bp)
3309 bp
RefSeq ID
NM_000180
RefSeq Synonyms
NM_000180, BC148421,
Species
human
UniGene ID
Hs.592109
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.