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human GLE1 shRNA silencing Adenovirus

Name 
Ad-h-GLE1-shRNA
Cat No 
shADV-209964
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GLE1.

shADV-209964
Ad-h-GLE1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GLE1 (GLE1, RNA export mediator). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
GLE1L; hGLE1; LCCS; LCCS1
Description (Vector)
GLE1 encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export. Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export. Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes. This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Gene ID
2733
Gene Name (Vector)
GLE1, RNA export mediator
Gene Symbol
GLE1
HGNC ID
HGNC:4315
ORF Size (aa)
2097
ORF Size (bp)
2097 bp
RefSeq ID
NM_001499
RefSeq Synonyms
NM_001499, NM_001003722, BC030012,
Species
human
UniGene ID
Hs.522418

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.