human GHRL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human GHRL.
shADV-209869
Ad-h-GHRL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human GHRL (ghrelin and obestatin prepropeptide). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
MTLRP
Description (Vector)
GHRL encodes ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor and is involved in regulating growth hormone release. Obestatin was initially reported to be an endogenous ligand for the orphan G protein-coupled receptor GPR39 and was involved in satiety and decreased food intake; however, these findings are controversial. Recent reports show that obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juice enzymes. Alternative promoters and alternative splicing result in multiple transcript variants, some of which encode different protein isoforms and some of which do not encode a protein but may regulate the ghrelin-obestatin preproprotein expression. In addition, antisense transcripts for this gene have been identified and may also function in regulation of the ghrelin-obestatin preproprotein expression.
Gene ID
51738
Gene Name (Vector)
ghrelin and obestatin prepropeptide
Gene Symbol
GHRL
HGNC ID
HGNC:18129
ORF Size (aa)
354
RefSeq ID
NM_016362
RefSeq Synonyms
NM_016362, NM_001302825, NM_001302824, NM_001302823, NM_001302822, NM_001302821, NM_001134946, NM_001134945, NM_001134944, NM_001134941, BC025791,
Species
human
UniGene ID
Hs.590080
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.