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human GFM1 shRNA silencing Adenovirus

Name 
Ad-h-GFM1-shRNA
Cat No 
shADV-209823
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GFM1.

shADV-209823
Ad-h-GFM1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GFM1 (G elongation factor mitochondrial 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
COXPD1; EFG; EFG1; EFGM; EF-Gmt; EGF1; Elongation factor G 1, mitochondrial; elongation factor G, mitochondrial; Elongation factor G1; G translation elongation factor, mitochondrial; GFM; hEFG1; mEF-G 1; mitochondrial elongation factor G; mitochondrial elongation factor G1; mtEF-G1
Description (eCommerce)
The protein elongation factor G, mitochondrial, is encoded by the gene GFM1, also known as EGF1. This mitochondrial GTPase is involved in the polypeptide chain elongation pathway [taken from UniProtKB (Entry: Q96RP9)].
Description (Vector)
Eukaryotes contain two protein translational systems, one in the cytoplasm and one in the mitochondria. Mitochondrial translation is crucial for maintaining mitochondrial function and mutations in this system lead to a breakdown in the respiratory chain-oxidative phosphorylation system and to impaired maintenance of mitochondrial DNA. This gene encodes one of the mitochondrial translation elongation factors. Its role in the regulation of normal mitochondrial function and in different disease states attributed to mitochondrial dysfunction is not known.
Gene ID
85476
Gene Name (eCommerce)
G elongation factor mitochondrial 1
Gene Name (Vector)
G elongation factor mitochondrial 1
Gene Symbol
GFM1
HGNC ID
HGNC:13780
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2256
ORF Size (bp)
2256 bp
Protein Name (eCommerce)
Elongation factor G, mitochondrial
RefSeq ID
NM_024996
RefSeq Synonyms
NM_024996, NM_001308166, NM_001308164, BC049210,
Research Areas
Immunology,Mitochondrion,Translational Control
Research Areas (Faceted)
cell_biology,immunology,transcription_translation
Species
human
Target Sentence
The protein elongation factor G, mitochondrial, is encoded by the gene GFM1, also known as EGF1. This mitochondrial GTPase is involved in the polypeptide chain elongation pathway [taken from UniProtKB (Entry: Q96RP9)].
UniGene ID
Hs.518355
UniProt ID (eCommerce)
Q96RP9

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.