human GEMIN4 shRNA silencing Adenovirus

Name
Ad-h-GEMIN4-shRNA

Cat No
shADV-209805

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human GEMIN4.

shADV-209805

Ad-h-GEMIN4-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GEMIN4 (gem nuclear organelle associated protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

component of gems 4; gem-associated protein 4; gemin-4; HC56; HCAP1; HCC-associated protein 1; HHRF-1; NEDMCR; p97

Description (eCommerce)

Gemin4 is a component of the SMN (survival of motor neurons) complex and also localizes to nuclear focal structures called gems or Gemini of coiled bodies. In the SMN complex Gemin4 interacts with the gemin3 DEAD box protein and several core components of the splicesome that mediates pre-mRNA splicing.

Description (Vector)

The product of this gene is part of a large complex localized to the cytoplasm, nucleoli, and to discrete nuclear bodies called Gemini bodies (gems). The complex functions in spliceosomal snRNP assembly in the cytoplasm, and regenerates spliceosomes required for pre-mRNA splicing in the nucleus. The encoded protein directly interacts with a DEAD box protein and several spliceosome core proteins. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Gene ID

50628

Gene Name (eCommerce)

gem nuclear organelle associated protein 4

Gene Name (Vector)

gem nuclear organelle associated protein 4

Gene Symbol

GEMIN4

HGNC ID

HGNC:15717

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

3177

ORF Size (bp)

3177 bp

Protein Name (eCommerce)

Gem-associated protein 4

RefSeq ID

NM_015721

RefSeq Synonyms

NM_015721, BC020062,

Research Areas

Gene Expression,mRNA Processing,mRNA Splicing,Neurobiology,RNA Processing,RNA Transport,Spliceosome

Research Areas (Faceted)

genetics,transcription_translation,neurobiology,cell_biology

Species

human

Target Sentence

Gemin4 is a component of the SMN (survival of motor neurons) complex and also localizes to nuclear focal structures called gems or Gemini of coiled bodies. In the SMN complex Gemin4 interacts with the gemin3 DEAD box protein and several core components of the splicesome that mediates pre-mRNA splicing.

UniGene ID

Hs.499620

UniProt ID (eCommerce)

P57678

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.