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human GART shRNA silencing Adenovirus

Name 
Ad-h-GART-shRNA
Cat No 
shADV-209652
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human GART.

shADV-209652
Ad-h-GART-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human GART (phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
5'-phosphoribosylglycinamide transformylase; AIR synthase; AIRS; GAR transformylase; GARS; GARS-AIRS-GART; GART; GARTF; glycinamide ribonucleotide formyltransferase; Glycinamide ribonucleotide synthetase; glycinamide ribonucleotide synthetase-aminoimidazole ribonucleotide synthetase-glycinamide ribonucleotide transformylase; PAIS; PGFT; Phosphoribosyl-aminoimidazole synthetase; Phosphoribosylformylglycinamidine cyclo-ligase; Phosphoribosylglycinamide formyltransferase; Phosphoribosylglycinamide synthetase; PRGS; trifunctional purine biosynthetic protein adenosine-3
Description (eCommerce)
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates [taken from NCBI Entrez Gene (Gene ID: 2618)].
Description (Vector)
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Gene ID
2618
Gene Name (eCommerce)
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene Name (Vector)
phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase
Gene Symbol
GART
HGNC ID
HGNC:4163
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3033
ORF Size (bp)
3033 bp
Protein Name (eCommerce)
Trifunctional purine biosynthetic protein adenosine-3
RefSeq ID
NM_000819
RefSeq Synonyms
NM_175085, NM_001136006, NM_001136005, NM_000819, BC107712,
Research Areas
Cancer,Metabolism/Metabolic Process,Methyltransferase
Research Areas (Faceted)
cancer,metabolism,cell_biology
Species
human
Target Sentence
GART is a trifunctional polypeptide. It has phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase activity which is required for de novo purine biosynthesis. This enzyme is highly conserved in vertebrates [taken from NCBI Entrez Gene (Gene ID: 2618)].
UniGene ID
Hs.473648
UniProt ID (eCommerce)
P22102

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.