human FXYD5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FXYD5.
shADV-209447
Ad-h-FXYD5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FXYD5 (FXYD domain containing ion transport regulator 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DYSAD; HSPC113; IWU1; KCT1; OIT2; PRO6241; RIC
Description (Vector)
FXYD5 encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD5 product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. (RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009)
Gene ID
53827
Gene Name (Vector)
FXYD domain containing ion transport regulator 5
Gene Symbol
FXYD5
HGNC ID
HGNC:4029
ORF Size (aa)
537
RefSeq ID
NM_014164
RefSeq Synonyms
NM_144779, NM_014164, NM_001320913, NM_001320912, NM_001164605, BC009642,
Species
human
UniGene ID
Hs.333418
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.