human FDFT1 shRNA silencing Adenovirus

Name
Ad-h-FDFT1-shRNA

Cat No
shADV-208885

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Human FDFT1.

shADV-208885

Ad-h-FDFT1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FDFT1 (farnesyl-diphosphate farnesyltransferase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

90

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

DGPT; ERG9; Farnesyl-diphosphate farnesyltransferase; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; squalene synthase; squalene synthetase; SS

Description (eCommerce)

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is a membrane-associated enzyme located at a branch point in the mevalonate pathway. FDFT1 is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene [taken from NCBI Entrez Gene (Gene ID: 2222)].

Description (Vector)

FDFT1 encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene.

Gene ID

2222

Gene Name (eCommerce)

farnesyl-diphosphate farnesyltransferase 1

Gene Name (Vector)

farnesyl-diphosphate farnesyltransferase 1

Gene Symbol

FDFT1

HGNC ID

HGNC:3629

NCBI Taxonomy ID (eCommerce)

9606.0

ORF Size (aa)

1254

ORF Size (bp)

1254 bp

Protein Name (eCommerce)

Squalene synthase

RefSeq ID

NM_004462

RefSeq Synonyms

NM_004462, NM_001287756, NM_001287751, NM_001287750, NM_001287749, NM_001287748, NM_001287747, NM_001287745, NM_001287744, NM_001287743, NM_001287742, BC029641, BC009251, BC003573,

Research Areas

Metabolism/Metabolic Process,Signal Transduction

Research Areas (Faceted)

cell_biology,metabolism,signal_transduction

Species

human

Target Sentence

Farnesyl-diphosphate farnesyltransferase 1 (FDFT1) is a membrane-associated enzyme located at a branch point in the mevalonate pathway. FDFT1 is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene [taken from NCBI Entrez Gene (Gene ID: 2222)].

UniGene ID

Hs.593928

UniProt ID (eCommerce)

P37268

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.