human FBL shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FBL.
shADV-208733
Ad-h-FBL-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FBL (fibrillarin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
34 kDa nucleolar scleroderma antigen; 34-kD nucleolar scleroderma antigen; FIB; FLRN; histone-glutamine methyltransferase; Nop1; RNA, U3 small nucleolar interacting protein 1; RNU3IP1; rRNA 2'-O-methyltransferase fibrillarin
Description (eCommerce)
Fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. Fibrillarin contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin [taken from NCBI Entrez Gene (Gene ID: 2091)].
Description (Vector)
FBL product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin.
Gene ID
2091
Gene Name (eCommerce)
fibrillarin
Gene Name (Vector)
fibrillarin
Gene Symbol
FBL
HGNC ID
HGNC:3599
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
966
ORF Size (bp)
966 bp
Protein Name (eCommerce)
rRNA 2'-O-methyltransferase fibrillarin
RefSeq ID
NM_001436
RefSeq Synonyms
NM_001436, BC019260,
Research Areas
Methyltransferase,RNA Binding,RNA Processing,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cell_biology,genetics,transcription_translation,signal_transduction
Species
human
Target Sentence
Fibrillarin is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. Fibrillarin contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin [taken from NCBI Entrez Gene (Gene ID: 2091)].
UniGene ID
Hs.299002
UniProt ID (eCommerce)
P22087
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.