human FASN shRNA silencing Adenovirus

Name 
Ad-h-FASN-shRNA
Cat No 
shADV-208722
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FASN.

shADV-208722
Ad-h-FASN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FASN (fatty acid synthase). Available with optional GFP reporter or cell-specific promoter.

Request a Quote

Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Acyl-carrier-protein S-acetyltransferase; Acyl-carrier-protein S-malonyltransferase; 3-hydroxyacyl-acyl-carrier-protein dehydratase; 3-oxoacyl-acyl-carrier-protein reductase; Enoyl-acyl-carrier-protein reductase; FAS; fatty acid synthase; OA-519; Oleoyl-acyl-carrier-protein hydrolase; SDR27X1; short chain dehydrogenase/reductase family 27X, member 1
Description (eCommerce)
Fatty acid synthase (FASN) is a multifunctional protein that is mainly involved in catalyzing the synthesis of long-chain fatty acids. FASN has recently been viewed as an important protein involved in carcinogenesis as it has been found to be constitutively active in subsets of carcinomas and is associated with a poor prognosis. The inhibition of FASN activity in cancer cells promotes apoptosis and thus may play a role in maintaining cancer cell survival.
Description (Vector)
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha.
Gene ID
2194
Gene Name (eCommerce)
fatty acid synthase
Gene Name (Vector)
fatty acid synthase
Gene Symbol
FASN
HGNC ID
HGNC:3594
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
7536
ORF Size (bp)
7536 bp
Protein Name (eCommerce)
Fatty acid synthase
RefSeq ID
NM_004104
RefSeq Synonyms
NM_004104, BC063242, BC007909,
Research Areas
Golgi Apparatus,Insulin Signaling,Metabolism/Metabolic Process,Mitochondrion,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,metabolism,cell_biology
Species
human
Target Sentence
Fatty acid synthase (FASN) is a multifunctional protein that is mainly involved in catalyzing the synthesis of long-chain fatty acids. FASN has recently been viewed as an important protein involved in carcinogenesis as it has been found to be constitutively active in subsets of carcinomas and is associated with a poor prognosis. The inhibition of FASN activity in cancer cells promotes apoptosis and thus may play a role in maintaining cancer cell survival.
UniGene ID
Hs.83190
UniProt ID (eCommerce)
P49327

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.