human FAM111B shRNA silencing Adenovirus

Name 
Ad-h-FAM111B-shRNA
Cat No 
shADV-208328
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human FAM111B.

shADV-208328
Ad-h-FAM111B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human FAM111B (family with sequence similarity 111 member B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cancer-associated nucleoprotein; CANP; POIKTMP; protein FAM111B
Description (eCommerce)
FAM111B has a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [taken from NCBI Entrez Gene (Gene ID: 374393)].
Gene ID
374393
Gene Name (eCommerce)
family with sequence similarity 111 member B
Gene Name (Vector)
family with sequence similarity 111 member B
Gene Symbol
FAM111B
HGNC ID
HGNC:24200
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2205
ORF Size (bp)
2205 bp
Protein Name (eCommerce)
Protein FAM111B
RefSeq ID
NM_198947
RefSeq Synonyms
NM_198947, NM_001142704, NM_001142703, BC130539, BC130513,
Research Areas
DNA Replication
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
FAM111B has a trypsin-like cysteine/serine peptidase domain in the C-terminus. Mutations in this gene are associated with an autosomal dominant form of hereditary fibrosing poikiloderma (HFP). Affected individuals display mottled pigmentation, telangiectasia, epidermal atrophy, tendon contractures, and progressive pulmonary fibrosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [taken from NCBI Entrez Gene (Gene ID: 374393)].
UniGene ID
Hs.186579
UniProt ID (eCommerce)
Q6SJ93

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.