human F13A1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human F13A1.
shADV-208219
Ad-h-F13A1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human F13A1 (coagulation factor XIII A chain). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
F13A
Description (Vector)
F13A1 encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Gene ID
2162
Gene Name (Vector)
coagulation factor XIII A chain
Gene Symbol
F13A1
HGNC ID
HGNC:3531
ORF Size (aa)
2199
ORF Size (bp)
2199 bp
RefSeq ID
NM_000129
RefSeq Synonyms
NM_000129, BC027963,
Species
human
UniGene ID
Hs.335513
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.