human F11 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human F11.
shADV-208216
Ad-h-F11-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human F11 (coagulation factor XI). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FXI
Description (Vector)
F11 encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
Gene ID
2160
Gene Name (Vector)
coagulation factor XI
Gene Symbol
F11
HGNC ID
HGNC:3529
ORF Size (aa)
1878
ORF Size (bp)
1878 bp
RefSeq ID
NM_000128
RefSeq Synonyms
NM_000128, BC122863, BC119014,
Species
human
UniGene ID
Hs.714107
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.