human EXOSC9 shRNA silencing Adenovirus

Name 
Ad-h-EXOSC9-shRNA
Cat No 
shADV-208197
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EXOSC9.

shADV-208197
Ad-h-EXOSC9-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EXOSC9 (exosome component 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
autoantigen PM/Scl 1; exosome complex component RRP45; exosome complex exonuclease RRP45; Exosome component 9; p5; p6; P75 polymyositis-scleroderma overlap syndrome associated autoantigen; P75 polymyositis-scleroderma overlap syndrome-associated autoantigen; PCH1D; PM/Scl-75; PMSCL autoantigen, 75kD; PMSCL1; Polymyositis/scleroderma autoantigen 1; polymyositis/scleroderma autoantigen 1, 75kDa; Polymyositis/scleroderma autoantigen 75 kDa; RRP45; Rrp45p
Description (eCommerce)
EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) http://www.uniprot.org/uniprot/Q06265.
Description (Vector)
EXOSC9 encodes a component of the human exosome, a exoribonuclease complex which processes and degrades RNA in the nucleus and cytoplasm. This component may play a role in mRNA degradation and the polymyositis/scleroderma autoantigen complex. Alternative splicing results in multiple transcript variants.
Gene ID
5393
Gene Name (eCommerce)
exosome component 9
Gene Name (Vector)
exosome component 9
Gene Symbol
EXOSC9
HGNC ID
HGNC:9137
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1320
ORF Size (bp)
1320 bp
Protein Name (eCommerce)
Exosome complex component RRP45
RefSeq ID
NM_005033
RefSeq Synonyms
NM_005033, NM_001034194, BC142978, BC140039, BC140038,
Research Areas
Gene Expression,Immunology,mRNA Binding,RNA Binding,RNA Processing
Research Areas (Faceted)
cell_biology,genetics,immunology,transcription_translation
Species
human
Target Sentence
EXOSC9 is a non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm [taken from the Universal Protein Resource (UniProt) http://www.uniprot.org/uniprot/Q06265.
UniGene ID
Hs.91728
UniProt ID (eCommerce)
Q06265

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.