human ERC1 shRNA silencing Adenovirus

Name 
Ad-h-ERC1-shRNA
Cat No 
shADV-208052
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ERC1.

shADV-208052
Ad-h-ERC1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ERC1 (ELKS/RAB6-interacting/CAST family member 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Cast2; ELKS; ELKS/Rab6-interacting/CAST family member 1; ERC-1; RAB6 interacting protein 2; Rab6-interacting protein 2; RAB6IP2
Description (eCommerce)
ERC1 (ELKS/RAB6-interacting/CAST family member 1) is a regulatory subunit of the IkappaB kinase (IKK) complex. ERC1 probably recruits IkappaBalpha/NFKBIA to the IKK complex. ERC1 may be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release, and may also be involved in vesicle trafficking at the CAZ. ERC1 is also likely involved in Rab-6 regulated endosomes-to- Golgi transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IUD2].
Description (Vector)
ERC1 is a member of a family of RIM-binding proteins. RIMs are active zone proteins that regulate neurotransmitter release. This gene has been found fused to the receptor-type tyrosine kinase gene RET by gene rearrangement due to the translocation t(10;12)(q11;p13). Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
23085
Gene Name (eCommerce)
ELKS/RAB6-interacting/CAST family member 1
Gene Name (Vector)
ELKS/RAB6-interacting/CAST family member 1
Gene Symbol
ERC1
HGNC ID
HGNC:17072
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2979
ORF Size (bp)
2979 bp
Protein Name (eCommerce)
ELKS/Rab6-interacting/CAST family member 1
RefSeq ID
NM_178040
RefSeq Synonyms
NM_178040, NM_178039, NM_001301248, BC150248, BC132784, BC132782, BC005065,
Research Areas
Cancer,Golgi Apparatus,Interleukin Signaling,Lung Cancer,Neurobiology,NF-kB Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
ERC1 (ELKS/RAB6-interacting/CAST family member 1) is a regulatory subunit of the IkappaB kinase (IKK) complex. ERC1 probably recruits IkappaBalpha/NFKBIA to the IKK complex. ERC1 may be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release, and may also be involved in vesicle trafficking at the CAZ. ERC1 is also likely involved in Rab-6 regulated endosomes-to- Golgi transport [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q8IUD2].
UniGene ID
Hs.658200
UniProt ID (eCommerce)
Q8IUD2

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.