human EIF4G1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human EIF4G1.
shADV-207793
Ad-h-EIF4G1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human EIF4G1 (eukaryotic translation initiation factor 4 gamma 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EIF4F; EIF4G; eIF-4G 1; EIF-4G1; EIF4-gamma; eIF-4-gamma 1; EIF4GI; eucaryotic translation initiation factor 4G; eukaryotic translation initiation factor 4 gamma 1; P220; PARK18
Description (eCommerce)
Eukaryotic initiation factor 4 gamma 1 (eIF4G1) is one of 2 eIF4G proteins found in human (eIF4G1 and eIF4G3). eIF4G is a subunit of the eIF4F heterotrimeric complex composed of eIF4A, eIF4E, and eIF4G. eIF4F plays a role in recruiting the ribosome to the 5’-end of capped mRNAs during protein synthesis. In the eIF4F complex, eIF4G functions as a scaffold to bridge the cap-binding subunit, eIF4E, with the RNA helicase, eIF4A.
Description (Vector)
EIF4G1 is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage.
Gene ID
1981
Gene Name (eCommerce)
eukaryotic translation initiation factor 4 gamma 1
Gene Name (Vector)
eukaryotic translation initiation factor 4 gamma 1
Gene Symbol
EIF4G1
HGNC ID
HGNC:3296
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
4821
ORF Size (bp)
4821 bp
Protein Name (eCommerce)
Eukaryotic translation initiation factor 4 gamma 1
RefSeq ID
NM_182917
RefSeq Synonyms
NM_198244, NM_198242, NM_198241, NM_182917, NM_004953, NM_001291157, NM_001194947, NM_001194946, BC140896, BC140892,
Research Areas
Apoptosis,Cardiology,Cardiovascular,Cytokine Signaling,EGFR Signaling,Gene Expression,Host-Virus Interactions,IFN Signaling,IGF-1 Signaling,Immunology,Insulin Signaling,Metabolism/Metabolic Process,mRNA Binding,mTOR Signaling,Neurobiology,Neurodegeneration,Parkinson's Disease,RNA Binding,RNA Processing,RNA Transport,Signal Transduction,Translational Control
Research Areas (Faceted)
cardiovascular,cell_biology,genetics,transcription_translation,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Eukaryotic initiation factor 4 gamma 1 (eIF4G1) is one of 2 eIF4G proteins found in human (eIF4G1 and eIF4G3). eIF4G is a subunit of the eIF4F heterotrimeric complex composed of eIF4A, eIF4E, and eIF4G. eIF4F plays a role in recruiting the ribosome to the 5’-end of capped mRNAs during protein synthesis. In the eIF4F complex, eIF4G functions as a scaffold to bridge the cap-binding subunit, eIF4E, with the RNA helicase, eIF4A.
UniGene ID
Hs.433750
UniProt ID (eCommerce)
Q04637
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.