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human EI24 shRNA silencing Adenovirus

Name 
Ad-h-EI24-shRNA
Cat No 
shADV-207690
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human EI24.

shADV-207690
Ad-h-EI24-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human EI24 (EI24, autophagy associated transmembrane protein). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ectopic P-granules autophagy protein 4 homolog; EPG4; etoposide induced 2.4; etoposide-induced protein 2.4 homolog; p53-induced gene 8 protein; PIG8; TP53I8; tumor protein p53 inducible protein 8
Description (eCommerce)
Etoposide-induced protein 2.4 (EI24) acts as a negative growth regulator via p53-mediated apoptosis pathway.EI24 regulates formation of degradative autolysosomes during autophagy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14681].
Description (Vector)
EI24 has higher expression in p53-expressing cells than in control cells and is an immediate-early induction target of p53-mediated apoptosis. The protein encoded by this gene contains six putative transmembrane domains and may suppress cell growth by inducing apoptotic cell death through the caspase 9 and mitochondrial pathways. EI24 is located on human chromosome 11q24, a region frequently altered in cancers. Alternative splicing results in two transcript variants encoding different isoforms.
Gene ID
9538
Gene Name (eCommerce)
EI24, autophagy associated transmembrane protein
Gene Name (Vector)
EI24, autophagy associated transmembrane protein
Gene Symbol
EI24
HGNC ID
HGNC:13276
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1023
ORF Size (bp)
1023 bp
Protein Name (eCommerce)
Etoposide-induced protein 2.4 homolog
RefSeq ID
NM_004879
RefSeq Synonyms
NM_004879, NM_001330419, NM_001290135, NM_001007277, BC002390,
Research Areas
Apoptosis,Autophagy,p53 Signaling,Signal Transduction
Research Areas (Faceted)
cell_biology,signal_transduction
Species
human
Target Sentence
Etoposide-induced protein 2.4 (EI24) acts as a negative growth regulator via p53-mediated apoptosis pathway.EI24 regulates formation of degradative autolysosomes during autophagy [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O14681].
UniGene ID
Hs.716416
UniProt ID (eCommerce)
O14681

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.