human E2F4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human E2F4.
shADV-207495
Ad-h-E2F4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human E2F4 (E2F transcription factor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E2F transcription factor 4, p107/p130-binding; E2F-4; p107/p130-binding protein; transcription factor E2F4
Description (eCommerce)
E2F4 is a member of the E2F family of transcription factors. It binds DNA at the E2 recognition site found in the promoter region of a number of genes involved in cell cycle regulation and DNA replication. E2F4 binds to pRb, p107, and p130. Via its interaction with p130, E2F4 plays an important role in maintaining G2 arrest during G2 phase checkpoint activation.
Description (Vector)
E2F4 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer.
Gene ID
1874
Gene Name (eCommerce)
E2F transcription factor 4
Gene Name (Vector)
E2F transcription factor 4
Gene Symbol
E2F4
HGNC ID
HGNC:3118
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1242
ORF Size (bp)
1242 bp
Protein Name (eCommerce)
Transcription factor E2F4
RefSeq ID
NM_001950
RefSeq Synonyms
NM_001950, BC033180,
Research Areas
Cancer,Cardiovascular,Cell Cycle,Gene Expression,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cardiovascular,cancer,cell_biology,cell_cycle,genetics,transcription_translation,immunology,signal_transduction
Species
human
Target Sentence
E2F4 is a member of the E2F family of transcription factors. It binds DNA at the E2 recognition site found in the promoter region of a number of genes involved in cell cycle regulation and DNA replication. E2F4 binds to pRb, p107, and p130. Via its interaction with p130, E2F4 plays an important role in maintaining G2 arrest during G2 phase checkpoint activation.
UniGene ID
Hs.108371
UniProt ID (eCommerce)
Q16254
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.