human DYNC1I2 shRNA silencing Adenovirus

Name 
Ad-h-DYNC1I2-shRNA
Cat No 
shADV-207461
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DYNC1I2.

shADV-207461
Ad-h-DYNC1I2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
cytoplasmic dynein 1 intermediate chain 2; Cytoplasmic dynein intermediate chain 2; DH IC-2; DIC74; DNCI2; dynein intermediate chain 2, cytosolic; dynein, cytoplasmic, intermediate polypeptide 2; IC2; testis tissue sperm-binding protein Li 66n
Description (eCommerce)
Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. DYNC1I2 is involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13409].
Gene ID
1781
Gene Name (eCommerce)
dynein cytoplasmic 1 intermediate chain 2
Gene Name (Vector)
dynein cytoplasmic 1 intermediate chain 2
Gene Symbol
DYNC1I2
HGNC ID
HGNC:2964
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1839
ORF Size (bp)
1839 bp
Protein Name (eCommerce)
Cytoplasmic dynein 1 intermediate chain 2
RefSeq ID
NM_001378
RefSeq Synonyms
NM_001378, NM_001320884, NM_001320883, NM_001320882, NM_001271790, NM_001271789, NM_001271788, NM_001271787, NM_001271786, NM_001271785, BC109375, BC091498, BC015038,
Research Areas
Antigen Processing and Presentation,Cell Cycle,Cytoskeleton,Host-Virus Interactions,Immunology,Transport
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,infectious_disease
Species
human
Target Sentence
Cytoplasmic dynein 1 intermediate chain 2 (DYNC1I2) acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. DYNC1I2 is involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q13409].
UniGene ID
Hs.546250
UniProt ID (eCommerce)
Q13409

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.