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human DSC2 shRNA silencing Adenovirus

Name 
Ad-h-DSC2-shRNA
Cat No 
shADV-207336
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DSC2.

shADV-207336
Ad-h-DSC2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DSC2 (desmocollin 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARVD11; CDHF2; DG2; DGII/III; DSC3
Description (Vector)
DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.
Gene ID
1824
Gene Name (Vector)
desmocollin 2
Gene Symbol
DSC2
HGNC ID
HGNC:3036
ORF Size (aa)
2706
ORF Size (bp)
2706 bp
RefSeq ID
NM_004949
RefSeq Synonyms
NM_024422, NM_004949, BC063291,
Species
human
UniGene ID
Hs.95612

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.