human DOK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DOK2.
shADV-207245
Ad-h-DOK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DOK2 (docking protein 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
docking protein 2; docking protein 2, 56kD; docking protein 2, 56kDa; downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
Description (eCommerce)
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. It may be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60496].
Description (Vector)
DOK2 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Gene ID
9046
Gene Name (eCommerce)
docking protein 2
Gene Name (Vector)
docking protein 2
Gene Symbol
DOK2
HGNC ID
HGNC:2991
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1239
ORF Size (bp)
1239 bp
Protein Name (eCommerce)
Docking protein 2
RefSeq ID
NM_003974
RefSeq Synonyms
NM_201349, NM_003974, NM_001317800, BC032623,
Research Areas
Angiogenesis,Cardiovascular,EGFR Signaling,Immunology,Interleukin Signaling,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
cancer,cardiovascular,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. It may be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity)Â [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O60496].
UniGene ID
Hs.71215
UniProt ID (eCommerce)
O60496
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.