human DOCK3 shRNA silencing Adenovirus

Name 
Ad-h-DOCK3-shRNA
Cat No 
shADV-207228
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DOCK3.

shADV-207228
Ad-h-DOCK3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DOCK3 (dedicator of cytokinesis 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
MOCA; PBP
Description (Vector)
DOCK3 is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins (Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins) via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. DOCK3 is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.
Gene ID
1795
Gene Name (Vector)
dedicator of cytokinesis 3
Gene Symbol
DOCK3
HGNC ID
HGNC:2989
ORF Size (aa)
6090
ORF Size (bp)
6090 bp
RefSeq ID
NM_004947
RefSeq Synonyms
NM_004947, BC157127, BC156339,
Species
human
UniGene ID
Hs.476284

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.