human DNM2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DNM2.
shADV-207204
Ad-h-DNM2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DNM2 (dynamin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; dynamin II; dynamin-2; DYNII; LCCS5
Description (eCommerce)
Dynamin 2 is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Dynamin 2 is most likely involved in vesicular trafficking processes, in particular endocytosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P0570].
Description (Vector)
Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined.
Gene ID
1785
Gene Name (eCommerce)
dynamin 2
Gene Name (Vector)
dynamin 2
Gene Symbol
DNM2
HGNC ID
HGNC:2974
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2613
ORF Size (bp)
2613 bp
Protein Name (eCommerce)
Dynamin-2
RefSeq ID
NM_004945
RefSeq Synonyms
NM_004945, NM_001190716, NM_001005362, NM_001005361, NM_001005360, BC054501, BC039596,
Research Areas
Antigen Processing and Presentation,Apoptosis,Axon Guidance,Cell Cycle,Cytoskeleton,Golgi Apparatus,Immunology,Innate Immunity,Interleukin Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodegeneration,Neurodevelopment,NGF Signaling,PDGF Signaling,Prolactin Signaling,Signal Transduction,Synapse,T-cell Receptor Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,Translational Control,Transport,VEGF Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation,immunology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
Dynamin 2 is a microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Dynamin 2 is most likely involved in vesicular trafficking processes, in particular endocytosis [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P0570].
UniGene ID
Hs.211463
UniProt ID (eCommerce)
P50570
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.