human DMPK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DMPK.
shADV-207094
Ad-h-DMPK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DMPK (dystrophia myotonica protein kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DM; DM1; DM1PK; DMK; MDPK; MT-PK
Description (Vector)
DMPK is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-37 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene ID
1760
Gene Name (Vector)
dystrophia myotonica protein kinase
Gene Symbol
DMPK
HGNC ID
HGNC:2933
ORF Size (aa)
1890
ORF Size (bp)
1890 bp
RefSeq ID
NM_004409
RefSeq Synonyms
NM_004409, NM_001288766, NM_001288765, NM_001288764, NM_001081563, NM_001081562, NM_001081560, BC062553, BC026328,
Species
human
UniGene ID
Hs.631596
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.