human DHX38 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human DHX38.
shADV-206973
Ad-h-DHX38-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human DHX38 (DEAH-box helicase 38). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
ATP-dependent RNA helicase DHX38; DDX38; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 38; DEAH (Asp-Glu-Ala-His) box polypeptide 38; DEAH box protein 38; pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16; PRP16; PRP16 homolog of S.cerevisiae; PRPF16
Description (eCommerce)
DHX38 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX38 is the human ortholog of the yeast Prp16 protein. DHX38 has been shown to be required for catalytic step II of pre-mRNA splicing.
Description (Vector)
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a member of the DEAD/H box family of splicing factors. This protein resembles yeast Prp16 more closely than other DEAD/H family members. It is an ATPase and essential for the catalytic step II in pre-mRNA splicing process.
Gene ID
9785
Gene Name (eCommerce)
DEAH-box helicase 38
Gene Name (Vector)
DEAH-box helicase 38
Gene Symbol
DHX38
HGNC ID
HGNC:17211
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3684
ORF Size (bp)
3684 bp
Protein Name (eCommerce)
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
RefSeq ID
NM_014003
RefSeq Synonyms
NM_014003, BC008340, BC004235,
Research Areas
Gene Expression,Helicase Activity,mRNA Processing,mRNA Splicing,mRNA Transport,RNA Processing,RNA Transport,Spliceosome
Research Areas (Faceted)
genetics,transcription_translation,cell_biology
Species
human
Target Sentence
DHX38 is a member of the DEAH box family of proteins that possesses several conserved motifs which include the highly conserved DEAH (Asp-Glu-Ala-His) amino acid sequence motif. The major activity of DEAH box proteins is to function as ATP-dependent RNA helicases. RNA helicases play an important role in all aspects of RNA metabolism and function which include pre-mRNA splicing, RNA synthesis, RNA degradation, RNA export, RNA translation, RNA secondary structure formation, ribosome biogenesis, and the assembly of RNP complexes. DHX38 is the human ortholog of the yeast Prp16 protein. DHX38 has been shown to be required for catalytic step II of pre-mRNA splicing.
UniGene ID
Hs.151218
UniProt ID (eCommerce)
Q92620
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.