human DEK shRNA silencing Adenovirus

Name 
Ad-h-DEK-shRNA
Cat No 
shADV-206862
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DEK.

shADV-206862
Ad-h-DEK-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DEK (DEK proto-oncogene). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
D6S231E; DEK oncogene (DNA binding); protein DEK
Description (eCommerce)
DEK is a chromatin-binding protein that may serve as an architectural protein at promoter or enhancer sites of particular genes and may be involved in the regulation of transcription and mRNA processing. DEK has been identified as an oncoprotein and an autoantigen.
Description (Vector)
DEK encodes a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
7913
Gene Name (eCommerce)
DEK proto-oncogene
Gene Name (Vector)
DEK proto-oncogene
Gene Symbol
DEK
HGNC ID
HGNC:2768
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1128
ORF Size (bp)
1128 bp
Protein Name (eCommerce)
Protein DEK
RefSeq ID
NM_003472
RefSeq Synonyms
NM_003472, NM_001134709, BC035259,
Research Areas
Cancer,Chromatin Remodeling,DNA Damage/Repair,Host-Virus Interactions,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,genetics,transcription_translation,infectious_disease,cancer
Species
human
Target Sentence
DEK is a chromatin-binding protein that may serve as an architectural protein at promoter or enhancer sites of particular genes and may be involved in the regulation of transcription and mRNA processing. DEK has been identified as an oncoprotein and an autoantigen.
UniGene ID
Hs.484813
UniProt ID (eCommerce)
P35659

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.